Genomic Analysis of Acinetobacter baumannii Isolates Carrying OXA-23 and OXA-58 Genes from Animals Reveals ST1 and ST25 as Major Clonal Lineages
Genomic Analysis of Acinetobacter baumannii Isolates Carrying OXA-23 and OXA-58 Genes from Animals Reveals ST1 and ST25 as Major Clonal Lineages
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Acinetobacter baumannii is increasingly being recognized as a relevant pathogen for animals with a putative zoonotic impact.This study aimed at identifying and characterizing carbapenemase-producing A.baumannii from animals.Among 503 A.baumannii, mainly isolated from dogs/cats (75.
7%) between 2013 and 2018, 42 isolates from 22 veterinary clinics (VCs) harboured blaOXA-58 (n = 29) or blaOXA-23 (n = 13).The blaOXA-58 gene was located on plasmids (11.4–21.1 kb) within different genetic surroundings (patterns A–D).BlaOXA-23 was embedded in Condensate Pump Tn2006 on the chromosome (n = 4; pattern a) or Tn2008 on plasmids (n = 9; 41.
2–71.3 kb; patterns b–e).The predominant IC1-ST1P-OXA-58 (66.7%; 96.4% cgMLST complex type (CT)-1808) was disseminated among 11 VCs in Germany.
Resistance islands AbaR3-like (n = 15) and AbaR10 (n = 1) have emerged CIRCUVEIN among ST1-isolates since 2016.IC7-ST25P-OXA-23 isolates (21.4%) occurred in seven VCs in Germany, France and Italy and differed in their resistance gene patterns from those of OXA-58 isolates.They were separated into six CTs, basically according to their regional origin.Other STs observed were ST10, ST578 and ST602.
In conclusion, OXA-23 and OXA-58 were linked with ST1 and ST25, two globally distributed lineages in humans.The suggested transmission of certain lineages within and among VCs together with the acquisition of AbaR islands hints at a successful dissemination of multidrug-resistant strains in the VC environment.